Haloperidol depot spc

Anti-epileptic medication (AED)
How do AEDs work?
Which drug is right for me?
Getting the dosage right
What about side effects?
Women and anti-epileptic medication
Emergency drug treatment
Missed doses
Stopping anti-epileptic medication
Surgery
Vagus/Vagal Nerve Stimulation (VNS)
Ketogenic diet
Complementary therapies
Lifestyle
And finally …. medical research

In clinical trials with oral olanzapine, clinically meaningful QTc prolongations (Fridericia QT correction [QTcF] ≥ 500 milliseconds [msec] at any time post-baseline in patients with baseline QTcF<500 msec) were uncommon (% to 1%) in patients treated with olanzapine, with no significant differences in associated cardiac events compared to placebo. In clinical trials with olanzapine powder for solution for injection or ZYPADHERA, olanzapine was not associated with a persistent increase in absolute QT or in QTc intervals. However, caution should be exercised when olanzapine is prescribed with medicines known to increase QTc interval, especially in the elderly, in patients with congenital long QT syndrome, congestive heart failure, heart hypertrophy, hypokalaemia or hypomagnesaemia.

It should not be used concomitantly with medications known to prolong the QTc interval (. 5-HT3 antagonists , tricyclic antidepressants , citalopram , etc.) as this may lead to an increased risk of QTc interval prolongation. [16] [2] Neither should it be given concurrently with lithium (medication) as it may increase the risk of lithium toxicity and neuroleptic malignant syndrome . [4] [5] [16] It should not be given concurrently with other antipsychotics due to the potential for this to increase the risk of side effects, especially neurological side effects such as neuroleptic malignant syndrome . [4] [5] [16] It should be avoided in patients on CNS depressants such as opioids, alcohol and barbiturates. [16]

Aripiprazole's mechanism of action is different from those of the other FDA-approved atypical antipsychotics (., clozapine , olanzapine , quetiapine , ziprasidone , and risperidone ). Rather than antagonizing the D 2 receptor , aripiprazole acts as a D 2 partial agonist . [51] [47] Aripiprazole is also a partial agonist at the 5-HT 1A receptor , and like the other atypical antipsychotics displays an antagonist profile at the 5-HT 2A receptor . [52] [53] It also antagonizes the 5-HT 7 receptor and acts as a partial agonist at the 5-HT 2C receptor , both with high affinity. The latter action may underlie the minimal weight gain seen in the course of therapy. [54] Aripiprazole has moderate affinity for histamine, α-adrenergic, and D4 receptors as well as the serotonin transporter , while it has no appreciable affinity for cholinergic muscarinic receptors. [43]

Haloperidol depot spc

haloperidol depot spc

Aripiprazole's mechanism of action is different from those of the other FDA-approved atypical antipsychotics (., clozapine , olanzapine , quetiapine , ziprasidone , and risperidone ). Rather than antagonizing the D 2 receptor , aripiprazole acts as a D 2 partial agonist . [51] [47] Aripiprazole is also a partial agonist at the 5-HT 1A receptor , and like the other atypical antipsychotics displays an antagonist profile at the 5-HT 2A receptor . [52] [53] It also antagonizes the 5-HT 7 receptor and acts as a partial agonist at the 5-HT 2C receptor , both with high affinity. The latter action may underlie the minimal weight gain seen in the course of therapy. [54] Aripiprazole has moderate affinity for histamine, α-adrenergic, and D4 receptors as well as the serotonin transporter , while it has no appreciable affinity for cholinergic muscarinic receptors. [43]

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