When researching HCG in a variety of clients, Dr. Simeons noticed that when a patient was put on a low dose of Human Chorionic Gonadotropin (HCG) coupled with a low calorie diet, that the client started to lose weight quickly. He also noticed that they were not losing muscle mass, just abnormal fat that had been stored away. While on the HCG diet, Dr. Simeons noticed a permanent change in the function of the diencephalon, particularly the hypothalamus. He saw that his patients could keep the weight they lost off long term, rather than having to yo-yo diet. He also noticed that in some cases, while weight may not have been lost, it may have helped move the abnormal fat more evenly throughout the body. There is a portion in the Pounds & Inches manuscript in regards to The Emaciated Lady. A woman sat down in his office looking sickly. He thought she may have cancer and was wondering which one of his colleagues he could refer her to. When she explained that she wanted to reduce he was confused by her answer. But when she stood up, he noticed that she may have a tiny waist, but she had enormous hips & thighs. By using the HCG diet, he managed to transfer the abnormal fat from her hips and thighs to the rest of her body. After 5 weeks on the program, she did not lose any weight, however she lost 8 inches around her hips and her skin looked fresh and healthy.