Order & Collect
Free next day collection from your choice of over 2,200 Boots stores
£ or free when you spend £45 or more
Next Day Delivery
£ - place before 7pm for delivery the next day. Excludes weekends
Named Day Delivery
£ - choose a weekday within the next 14 days for delivery
£ - usually delivered between 7am - 1pm
For more information see our delivery help or view our returns policy .
Depressants are psychoactive drugs that temporarily diminish the function or activity of a specific part of the body or mind.  Colloquially, depressants are known as "downers", and users generally take them to feel more relaxed and less tense. Examples of these kinds of effects may include anxiolysis, sedation, and hypotension. Depressants are widely used throughout the world as prescription medicines and as illicit substances . When these are used, effects may include anxiolysis (reduction of anxiety), analgesia (pain relief), sedation , somnolence , cognitive/memory impairment, dissociation , muscle relaxation, lowered blood pressure / heart rate , respiratory depression , anesthesia , and anticonvulsant effects. Depressants exert their effects through a number of different pharmacological mechanisms, the most prominent of which include facilitation of GABA or opioid activity, and inhibition of adrenergic , histamine or acetylcholine activity. Some are also capable of inducing feelings of euphoria (a happy sensation).