This, by the way, leads to a perilous tissue accumulation of estrogen. Researcher have discovered this in the prostate. [ 12 ] In fact, that same study concluded that "the prostatic accumulation of DHT, estradiol, and estrone is in part intimately correlated with aging". Estradiol and estrone are two forms of estrogen, neither of which do you want accumulating in your tissues. In other words, male menopause or andropause is as much about estrogen as it is about testosterone .
Endogenous androgens are responsible for normal growth and development of the male sex organs and for maintenance of secondary sex characteristics. These effects include growth and maturation of the prostate , seminal vesicles , penis , and scrotum ; development of male hair distribution, such as beard , pubic, chest, and axillary hair; laryngeal enlargement, vocal cord thickening, and alterations in body musculature and fat distribution. Drugs in this class also cause retention of nitrogen , sodium, potassium , and phosphorous, and decreased urinary excretion of calcium. Androgens have been reported to increase protein anabolism and decrease protein catabolism . Nitrogen balance is improved only when there is sufficient intake of calories and protein.