Other side effects include increased risk of heart problems in older men with poor mobility, according to a 2009 study at Boston Medical Center. A 2017 study published in JAMA found that treatments increase coronary artery plaque volume. Additionally, the Food and Drug Administration (FDA) requires manufactures to include a notice on the labeling that states taking testosterone treatments can lead to possible increased risk of heart attacks and strokes. The FDA recommends that patients using testosterone should seek medical attention right away if they have these symptoms:
"The study fails for the most basic of reasons," Morgantaler told MedPage Today via email. "The authors treated all men receiving a testosterone prescription as if this were a homogeneous group and the selection of treatment options (injections, gels, patches) were random. However, multiple factors play a role in the choice of testosterone treatment options, including clinical presentation, testosterone concentrations, and economics (injections are considerably less expensive than patches and gels), none of which are addressed by the authors."